Serratiopeptidase is a proteolytic enzyme, it breaks down protein. Because it is a protein-digesting enzyme, how and when it is taken relative to food is part of how it is commonly formulated and labeled.
Why timing is part of the label directions
Taken with a meal, serrapeptase has protein from that meal available to act on. That is part of the reasoning behind label directions that recommend taking it between meals, on an empty stomach, rather than with food.
Delayed release is the other half
Stomach acid can break down enzymes before they move further through the digestive tract. Delayed-release capsules are designed to help protect the enzyme from the stomach environment before it reaches the small intestine. Serrapeptase is commonly formulated for use between meals rather than with food. Delayed-release capsules are intended to help protect the enzyme from the stomach environment. However, evidence about oral absorption, systemic activity and long-term clinical effects remains limited.
What we do not claim
We do not claim that oral serrapeptase reliably reaches circulation intact, and we do not make claims about inflammation resolution or respiratory comfort. AvalonX Serrapeptase 125 is formulated as a delayed-release capsule intended for empty-stomach use, consistent with common label conventions for this enzyme, while the underlying research base continues to develop.
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This article is for educational purposes only and is not medical advice. Consult a qualified healthcare practitioner regarding supplements, medications, or health conditions.